EQUILIBRIUM DIALYSIS STUDIES OF THE BINDING OF THYROXINE BY HUMAN SERUM ALBUMIN*
نویسندگان
چکیده
منابع مشابه
Binding of Thyroxine by Human Serum Albumin
In previous work from this laboratory (1) studies on equilibrium dialysis were carried out to determine the binding constants for the interaction of human serum albumin with thyroxine and its analogs. The classical technique of equilibrium dialysis as described by Scatchard and others (2-6) was employed. At present it seems clear that thyroxine in human serum migrates to at least three differen...
متن کاملThyroxine Binding by Human Serum Albumin*
Thyroxine and triiodothyronine are transported in the blood as noncovalent complexes with certain serum proteins. This has been shown by many investigators and was the subject of an extensive recent review by Robbins and Rall (1). The binding proteins are an a-globulin (called thyroxine-binding globulin), a prealbumin, and serum albumin. The first appears to be the most significant binder of th...
متن کاملThyroxine binding by human serum albumin.
Thyroxine and triiodothyronine are transported in the blood as noncovalent complexes with certain serum proteins. This has been shown by many investigators and was the subject of an extensive recent review by Robbins and Rall (1). The binding proteins are an a-globulin (called thyroxine-binding globulin), a prealbumin, and serum albumin. The first appears to be the most significant binder of th...
متن کاملMolecular dynamics simulation and docking studies on the binding properties of several anticancer drugs to human serum albumin
Disposition and transportation of anticancer drugs by human serum albumin (HSA) affects their bioavailability, distribution and elimination. In this study, the interaction of a set of anticancer drugs with HSA was investigated by molecular dynamics and molecular docking simulations. The drugs' activities were analyzed according to their docking scores, binding sites and structural descriptors. ...
متن کاملProbing the Binding of Valacyclovir Hydrochloride to the Human Serum Albumin
UV-visible and Fluorescence spectroscopic methods were employed to study the interaction of human serum albumin (HSA) with Valacyclovir Hydrochloride. Additionally, molecular dynamics and molecular docking simulations were used to visualize and specify the binding site of Valacyclovir Hydrochloride. The Stern-Volmer and van't Hoff equations along with spectroscopic observations, were used to de...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1962
ISSN: 0021-9738
DOI: 10.1172/jci104552